Last updated: 21 February2023
Growing Up in Singapore Towards healthy Outcomes (GUSTO) study is a major collaborative research effort involving partners across Singapore from healthcare and research alike. This includes the National University of Singapore (NUS), KK Women's and Children's Hospital (KKH), and A*STAR's Singapore Institute for Clinical Sciences (SICS). The purpose of GUSTO cohort study is to understand how conditions in pregnancy and early childhood influence the subsequent health and development of women and children.
Over the course of 2009 and 2010, Singaporean women were enrolled in GUSTO, from a point in early pregnancy. With the longitudinal cohort study being in its 12th year, mother-child dyads have been extensively phenotyped with continuous collection of data. As the GUSTO children journey through life, we are there every step of the way. The detailed observations and sampling on these mothers and children have been instrumental in discovering features more representative of the local and Asian population that can be used to improve the health and potential of our communities, with an earlier start.
Families attending their first trimester antenatal dating ultrasound scan clinic at National University of Hospital (NUH) and KK Women’s Children’s Hospital (KKH) were recruited into the cohort study. Informed written consent was obtained from each participant.
The research team recruited 1,450 pregnant women at 7-11 weeks of pregnancy between June 2009 to October 2010. There were a total of 1,344 natural pregnancies, 96 In-Vitro Fertilization (IVF) pregnancies and 10 natural twin pregnancies. 18 additional infants of low birthweight (PEGS cohort) were enrolled at delivery timepoint. In total, there were 1209 deliveries in the parent-offspring cohort (56.0% Chinese, 18.5% Malay, 25.4% Indian, 0.1% Others). The current attrition rate is 25.2% (with reference to delivery timepoint).
The active subject counts are displayed under each study timepoint (mother/child dyads from sub-cohorts). Lost to follow up counts are displayed after individual study timepoints. Active subject refers to active participants during each study timepoint. The completion rate for each instrument (at each study timepoint) would be a subset of active subject count as some of them may have missed a particular visit/timepoint. Lost to follow up refers to subjects who were actively participating in the study and became lost at a follow-up timepoint.
The baseline demographics for women in the PEGS cohort (n=18) were retrospectively obtained during enrolment visit. In total, baseline data for 1468 (1450+18) women were obtained.